non-alcoholic steatohepatitis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27061	CP-24879 hydrochloride	CP-24879 HCl	Others
	CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an...		Others
T31964	Glycolithocholic acid	Lithocholic acid glycine conjugate,Lithocholylglycine	Others
	Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.		Others
T77099	Nimacimab	JNJ 2463,RYI-018	Others
	Nimacimab is a recombinant humanized monoclonal antibody. It can improve diabetes and non-alcoholic steatohepatitis.		Others
T11661	INT-767		FXR , GPCR19
	INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.		FXR , GPCR19
T14301	Apararenone	MT-3995	Glucocorticoid Receptor
	Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.		Glucocorticoid Receptor
T64334	Glycolithocholic acid, sodium salt		Others
	Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s...		Others
T9186	Ervogastat	PF-06865571	Transferase
	Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).		Transferase
T76700	Simtuzumab	GS 6624,AB 0024	Monoamine Oxidase
	Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato...		Monoamine Oxidase
T37526	2-Oleoylglycerol	2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR
	2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglyce...		GPR
T77059	Leronlimab	PRO 140	CCR
	Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronl...		CCR
T67974	Berberine ursodeoxycholate	HTD1801,BUDCA
	Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly red...
T17236	Volixibat	SHP626,LUM002	Others
	Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.		Others
T74421	Pemvidutide
	Pemvidutide, a dual GLP-1R/GCGR agonist, significantly lowers body weight, liver fat, and serum lipids, holding promise for non-alcoholic steatohepatitis (NASH) and obesity research [1].
T81802	MGAT2-IN-4
	MGAT2-IN-4 (compound 33) serves as a monoacylglycerol acyltransferase 2 (MGAT2) inhibitor, exhibiting liver metabolic stability. This compound is applicable in obesity, diabetes, and non-alcoholic steatohepatitis (NASH) ...
T35636	SHS4121705
	SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis...
T78658	Pemvidutide TFA
	Pemvidutide (TFA), a GLP-1R/GCGR dual agonist, effectively reduces body weight, liver fat, and serum lipid levels, and is utilized in research on non-alcoholic steatohepatitis (NASH) and obesity [1].
T74996	FXR agonist 3
	FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ...
T79698	S217879
	S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway. This compound is applicable in research on non-alcoholic steatohepati...
T77175	Efruxifermin
	Efruxifermin, an Fc-FGF21 fusion protein consisting of a human IgG1 Fc domain linked to modified human FGF21, exhibits a prolonged half-life and enhanced receptor affinity compared to its native counterpart. It is utiliz...
T63777	QH536
	QH536 is an effective degrader of HMGCR (EC50: 0.22 μM).QH536 exhibits anti-inflammatory effects and does not have the side effect of inducing intracellular accumulation of cholesterol.QH536 can be used to study cardiova...